A novel solid support for synthesis of oligonucleotide 3'-phosphorothioate monoesters.
Bioorg Med Chem Lett
; 13(2): 281-4, 2003 Jan 20.
Article
em En
| MEDLINE
| ID: mdl-12482440
ABSTRACT
A new reagent immobilized on solid support allowing for solid-phase synthesis of oligonucleotides with a 3'-terminal phosphorothioate monoester is described. The support is compatible with phosphoramidite chemistry for automated oligonucleotide synthesis. Final deprotection with ammonia under standard conditions leads to oligonucleotide 3'-terminal phosphorothioate.
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Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Compostos Organotiofosforados
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article