Detection of JC virus infection in progressive multifocal leukoencephalopathy: the first documented case in Thailand.
J Med Assoc Thai
; 85(10): 1139-44, 2002 Oct.
Article
em En
| MEDLINE
| ID: mdl-12501908
ABSTRACT
Progressive Multifocal Leukoencephalopathy (PML) is a demyelinating brain disease caused by human polyoma JC virus (JCV). This disease is an important cause of morbidity and mortality in AIDS patients. Definite diagnosis currently requires a brain biopsy. PCR for JCV of CSF, an emerging diagnostic tool, has a high specificity for the diagnosis of PML in patients with characteristics on clinical and neuroradiological findings. The authors report a 36-year-old woman who presented with prolonged fever, progressive weakness, and slow speech for 2 months. Clinical features and MRI findings were compatible with PML. Qualitative PCR for JCV of CSF showed a positive result. This report emphasizes the yield of PCR, the CSF for JCV in a diagnosis of PML, which may reduce the need for a brain biopsy in such cases.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome da Imunodeficiência Adquirida
/
Leucoencefalopatia Multifocal Progressiva
/
Vírus JC
Tipo de estudo:
Diagnostic_studies
/
Qualitative_research
Limite:
Adult
/
Female
/
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article