The SBASE domain sequence library, release 10: domain architecture prediction.
Nucleic Acids Res
; 31(1): 403-5, 2003 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-12520034
ABSTRACT
SBASE (http//www.icgeb.trieste.it/sbase) is an on-line collection of protein domain sequences and related computational tools designed to facilitate detection of domain homologies based on simple database search. The 10th 'jubilee release' of the SBASE library of protein domain sequences contains 1 052 904 protein sequence segments annotated by structure, function, ligand-binding or cellular topology, clustered into over 6000 domain groups. Domain identification and functional prediction are based on a comparison of BLAST search outputs with a knowledge base of biologically significant similarities extracted from known domain groups. The knowledge base is generated automatically for each domain group from the comparison of within-group ('self') and out-of-group ('non-self') similarities. This is a memory-based approach wherein group-specific similarity functions are automatically learned from the database.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Estrutura Terciária de Proteína
/
Bases de Dados de Proteínas
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article