Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion.
Neuron
; 37(1): 121-33, 2003 Jan 09.
Article
em En
| MEDLINE
| ID: mdl-12526778
ABSTRACT
Here we describe a novel mechanism for plasma membrane insertion of the delta opioid receptor (DOR). In small dorsal root ganglion neurons, only low levels of DORs are present on the cell surface, in contrast to high levels of intracellular DORs mainly associated with vesicles containing calcitonin gene-related peptide (CGRP). Activation of surface DORs caused Ca(2+) release from IP(3)-sensitive stores and Ca(2+) entry, resulting in a slow and long-lasting exocytosis, DOR insertion, and CGRP release. In contrast, membrane depolarization or activation of vanilloid and P2Y(1) receptors induced a rapid DOR insertion. Thus, DOR activation induces a Ca(2+)-dependent insertion of DORs that is coupled to a release of excitatory neuropeptides, suggesting that treatment of inflammatory pain should include blockade of DORs.
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Base de dados:
MEDLINE
Assunto principal:
Nociceptores
/
Membrana Celular
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Receptores Opioides delta
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Exocitose
/
Gânglios Espinais
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Neurônios Aferentes
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article