First synthesis of the A/B ring of ouabain.
Org Lett
; 5(2): 137-40, 2003 Jan 23.
Article
em En
| MEDLINE
| ID: mdl-12529124
ABSTRACT
[reaction see text] The synthesis of the fully fuctionalized A/B ring of ouabain has been accomplished efficiently from commercially available starting materials. A key Robinson annulation allows for the building of the desired carbon framework in one high-yielding step. Directed epoxidation followed by selective epoxide opening furnished the final tetraol with the desired all-cis stereochemistry.
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Base de dados:
MEDLINE
Assunto principal:
Ouabaína
/
Cardiotônicos
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article