MPID: MHC-Peptide Interaction Database for sequence-structure-function information on peptides binding to MHC molecules.
Bioinformatics
; 19(2): 309-10, 2003 Jan 22.
Article
em En
| MEDLINE
| ID: mdl-12538264
ABSTRACT
SUMMARY:
Binding of short antigenic peptides to Major histocompatibility complex (MHC) proteins is the first step in T-cell mediated immune response. To understand the structural principles governing MHC-specific peptide recognition and binding, we have developed the MHC-Peptide Interaction Database (MPID), containing sequence-structure-function information. MPID (version 1.2) contains curated x-ray crystallographic data on 86 MHC peptide complexes, with precomputed interaction parameters (solvent accessibility, hydrogen bonds, gap volume and gap index). A user-friendly web interface and query tools will facilitate the development of predictive algorithms for MHC-peptide binding from a structural viewpoint.AVAILABILITY:
Freely accessible from http//surya.bic.nus.edu.sg/mpid.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Relação Estrutura-Atividade
/
Sistemas de Gerenciamento de Base de Dados
/
Bases de Dados de Proteínas
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Complexo Principal de Histocompatibilidade
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article