Impaired angiogenesis in neuropeptide Y (NPY)-Y2 receptor knockout mice.
Peptides
; 24(1): 99-106, 2003 Jan.
Article
em En
| MEDLINE
| ID: mdl-12576090
ABSTRACT
Which of Y1-Y5 receptors (Rs) mediate NPY's angiogenic activity was studied using Y2R-null mice and R-specific antagonists. In Y2R-null mice, NPY-induced aortic sprouting and in vivo Matrigel capillary formation were decreased by 50%; Y1R-antagonist blocked the remaining response. NPY-induced sprouting was equally inhibited by Y2R- (and Y5R- but less by Y1R-) antagonists in wild type mice. Spontaneous and NPY-induced revascularization of ischemic gastrocnemius muscles were similarly reduced in Y2R-null mice. Thus, NPY-induced angiogenesis, spontaneous and ischemic, is primarily mediated by Y2Rs. However, Y5Rs and, to a lesser degree Y1Rs, also may play a role in NPY-mediated angiogenesis.
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Base de dados:
MEDLINE
Assunto principal:
Receptores de Neuropeptídeo Y
/
Neovascularização Fisiológica
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article