Genetic variability of the frameshift region in IS911 transposable elements from Escherichia coli clinical isolates.
FEMS Microbiol Lett
; 218(2): 231-7, 2003 Jan 28.
Article
em En
| MEDLINE
| ID: mdl-12586397
ABSTRACT
The IS911 bacterial transposable element has been analyzed for its mechanism of transposition and for the way it controls the expression of its genes by programmed -1 translational frameshifting. In the present study the prevalence of IS911 has been determined in the Enterobacteriaceae family and in other Gram-negative bacilli. Three variants, found in Escherichia coli clinical isolates and having mutations in the region implicated in frameshifting, were functionally characterized. All three were altered in their frameshifting and transposition abilities, suggesting that the frameshift region of IS911 may constitute a target for mutations reducing the transposition frequency of this mobile element in natural populations of E. coli.
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Base de dados:
MEDLINE
Assunto principal:
Elementos de DNA Transponíveis
/
Mutação da Fase de Leitura
/
Escherichia coli
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article