Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline.
Nat Neurosci
; 6(3): 223-30, 2003 Mar.
Article
em En
| MEDLINE
| ID: mdl-12592406
ABSTRACT
Neuronal connectivity is established by the axo-dendritic polarity, correct guidance and targeting of neurons. Unlike for axons, the mechanisms responsible for directed outgrowth of dendrites are not well understood. Using single-cell labeling, we describe specific guidance defects in dendrites of identified neurons in frazzled, robo, netrin and commissureless mutant embryos of Drosophila melanogaster. We found that the cell-surface molecules Frazzled and Robo work as guidance molecules not only for axons but also for dendrites as they navigate within the CNS. Furthermore, we report that each neuron showed a cell-autonomous and independent use of guidance molecules.
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Base de dados:
MEDLINE
Assunto principal:
Receptores Imunológicos
/
Sistema Nervoso Central
/
Receptores de Superfície Celular
/
Proteínas de Drosophila
/
Dendritos
Tipo de estudo:
Guideline
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article