Central hypertensive action of histamine in conscious normotensive cats.
Eur J Pharmacol
; 36(1): 263-6, 1976 Mar.
Article
em En
| MEDLINE
| ID: mdl-1261600
ABSTRACT
In conscious normotensive cats intraventricular (i.c.v.) administration of histamine (2.0-50.0 mug) induced dose-related rises in blood pressure, with no increase in heart rate. The hypertensive response elicited by a sub-maximal dose of histamine (10.0 mu i.c.v.) was significantly antagonised by central pretreatment with the H1-receptor antagonist mepyramine maleate (200 mug i.c.v.) but not by the H2-receptor antagonist metiamide hydrochloride (1.0 mg i.c.v.). Behavioural responses were obtained in response to to histamine (10.0 and 50.0 mug i.c.v.), which were not antagonised by these antihistamine pretreatments.
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Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Histamina
Limite:
Animals
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Article