Polyglycine II nanosheets: supramolecular antivirals?
Chembiochem
; 4(2-3): 147-54, 2003 Mar 03.
Article
em En
| MEDLINE
| ID: mdl-12616627
ABSTRACT
Tetraantennary peptides [glycine(n)-NHCH(2)](4)C can form stable noncovalent structures by self-assembly through intermolecular hydrogen bonding. The oligopeptide chains assemble as polyglycine II to yield submicron-sized, flat, one-molecule-thick sheets. Attachment of alpha-N-acetylneuraminic acid (Neu5Acalpha) to the terminal glycine residues gives rise to water-soluble assembled glycopeptides that are able to bind influenza virus multivalently and inhibit adhesion of the virus to cells 10(3)-fold more effectively than a monomeric glycoside of Neu5Acalpha. Another antiviral strategy based on virus-promoted assembly of the glycopeptides was also demonstrated. Consequently, the self-assembly principle offers new perspectives on the design of multivalent antivirals.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Peptídeos
/
Nanotecnologia
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article