Regulatory T cells in transplantation tolerance.
Nat Rev Immunol
; 3(3): 199-210, 2003 Mar.
Article
em En
| MEDLINE
| ID: mdl-12658268
ABSTRACT
The identification and characterization of regulatory T (T(Reg)) cells that can control immune responsiveness to alloantigens have opened up exciting opportunities for new therapies in transplantation. After exposure to alloantigens in vivo, alloantigen-specific immunoregulatory activity is enriched in a population of CD4+ T cells that express high levels of CD25. In vivo, common mechanisms seem to underpin the activity of CD4+CD25+ T(Reg) cells in both naive and manipulated hosts. However, the origin, allorecognition properties and molecular basis for the suppressive activity of CD4+CD25+ T(Reg) cells, as well as their relationship to other populations of regulatory cells that exist after transplantation, remain a matter of debate..
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Base de dados:
MEDLINE
Assunto principal:
Imunologia de Transplantes
/
Subpopulações de Linfócitos
/
Linfócitos T Reguladores
/
Tolerância ao Transplante
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article