Peptide nucleic acid-metal complex conjugates: facile modulation of PNA-DNA duplex stability.
Bioorg Med Chem Lett
; 13(8): 1399-401, 2003 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-12667999
ABSTRACT
Conjugates of peptide nucleic acids (PNA) and metal binding ligands were prepared using solid-phase synthesis. Stability of duplexes of bis-picolylamine-PNA conjugates and DNA was found to be modulated by equimolar concentrations of bioavailable metal ions Ni(2+), Zn(2+)>Cu(2+). Sequence specificity of PNA was not compromised in the presence of these metal ions.
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Base de dados:
MEDLINE
Assunto principal:
DNA
/
Metais Pesados
/
Ácidos Nucleicos Peptídicos
/
Ácidos Nucleicos Heteroduplexes
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article