A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells.
J Immunol
; 170(8): 4102-10, 2003 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-12682240
ABSTRACT
Dendritic cells (DCs) are capable of cross-presenting exogenous Ag to CD8(+) CTLs. Detection of microbial products by Toll-like receptors (TLRs) leads to activation of DCs and subsequent orchestration of an adaptive immune response. We hypothesized that microbial TLR ligands could activate DCs to cross-present Ag to CTLs. Using DCs and CTLs in an in vitro cross-presentation system, we show that a subset of microbial TLR ligands, namely ligands of TLR3 (poly(inosinic-cytidylic) acid) and TLR9 (immunostimulatory CpG DNA), induces cross-presentation. In contrast to presentation of Ag to CD4(+) T cells by immature DCs, TLR-induced cross-presentation is mediated by mature DCs, is independent of endosomal acidification, and relies on cytosolic Ag processing machinery.
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Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Células da Medula Óssea
/
Glicoproteínas de Membrana
/
Apresentação de Antígeno
/
Receptores de Superfície Celular
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article