Derivatization of (+/-)-5-[(2-methylphenoxy)methyl]-2-amino-2-oxazoline, an imidazoline binding sites ligand, with (+)-(R)-alpha-methylbenzyl isocyanate for drug monitoring purposes.
J Enzyme Inhib Med Chem
; 17(6): 375-9, 2002 Dec.
Article
em En
| MEDLINE
| ID: mdl-12683672
ABSTRACT
The derivatization of racemic 5-[(2-methylphenoxy)methyl]-2-amino-2-oxazoline, developed as an imidazoline binding sites ligand, with (+)-(R)-alpha-methylbenzyl isocyanate was performed in chloroform. The reaction led to two pairs of diastereomers, which were separated by RP-HPLC. A kinetic study of the derivatization reaction was achieved in order to establish conditions suitable for experimental drug monitoring.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Oxazóis
/
Monitoramento de Medicamentos
/
Isocianatos
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article