IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Nat Immunol
; 4(5): 491-6, 2003 May.
Article
em En
| MEDLINE
| ID: mdl-12692549
ABSTRACT
The transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB are required for the expression of many genes involved in the innate immune response. Viral infection, or the binding of double-stranded RNA to Toll-like receptor 3, results in the coordinate activation of IRF3 and NF-kappaB. Activation of IRF3 requires signal-dependent phosphorylation, but little is known about the signaling pathway or kinases involved. Here we report that the noncanonical IkappaB kinase homologs, IkappaB kinase-epsilon (IKKepsilon) and TANK-binding kinase-1 (TBK1), which were previously implicated in NF-kappaB activation, are also essential components of the IRF3 signaling pathway. Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteínas Serina-Treonina Quinases
/
Proteínas de Drosophila
/
Proteínas de Ligação a DNA
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article