Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering.
Proc Natl Acad Sci U S A
; 100(9): 5348-53, 2003 Apr 29.
Article
em En
| MEDLINE
| ID: mdl-12695569
ABSTRACT
To better understand how innate and adaptive immune responses interact with each other, we combined 4-1BB T cell costimulation with specific adjuvants to determine whether these treatments would influence specific T cell expansion and function in vivo. In the presence of 4-1BB ligation and Toll-like receptor 3 (TLR)3 and/or TLR4 triggering, CD8 T cell clonal expansion and survival was augmented profoundly. Specific T cells primed in vivo with TLR ligands responded normally to in vitro recall stimulus, but, surprisingly, copriming with 4-1BB costimulation significantly impaired the recall response even though many more specific effector T cells were rescued in vivo. Here, we demonstrate that the rescued CD8 T cells suppressed CD4 T cell proliferation via a type beta transforming growth factor-dependent mechanism. Thus, 4-1BB and TLR ligands induce survival of specific effector CD8 T cells with suppressive recall potential, which may explain the dual role that 4-1BB activation plays in mediating tumor clearance and prevention of autoimmune disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
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Receptores de Fator de Crescimento Neural
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Receptores do Fator de Necrose Tumoral
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Receptores de Superfície Celular
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Linfócitos T CD8-Positivos
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Proteínas de Drosophila
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article