Rapeseed oil ingestion and exacerbation of hypertension-related conditions in stroke prone spontaneously hypertensive rats.
Toxicology
; 187(2-3): 205-16, 2003 May 03.
Article
em En
| MEDLINE
| ID: mdl-12699909
ABSTRACT
Two groups of 20 stroke prone spontaneously hypertensive rats (SHRSP) at 5 weeks old were fed a diet containing 10 w/w% rapeseed (canola) oil or soybean oil as the only dietary fat, and given drinking water containing 1% NaCl. Life span of the canola oil group (62+/-2 days) was shorter than that of the soybean oil group (68+/-3 days). Stroke-related symptoms were observed in every animal, but the onset of those in the canola oil group, at 47+/-1 days after starting the administration was earlier than that in the soybean oil group, 52+/-2 days. Incidence of cerebral hemorrhage was similar in these groups, and no differences were found between lesions of organs in the groups. In another experiment, two groups of ten SHRSP at 5 weeks of age were fed the defatted diet and given canola oil or soybean oil by gavage at 10 w/w% of consumed food for 4 weeks without NaCl loading. After the 4-week administration, mean systolic blood pressure in the canola oil group and the soybean oil group were 233+/-2 and 223+/-0.3 mmHg, respectively. Phytosterol levels in both plasma and erythrocyte membranes reflected those contained in the oils ingested. Na(+), K(+)-ATPase activities in the brain, heart and kidney were enhanced in the canola oil group. These results indicate that promotion of hypertension-related deterioration in organs is likely to have relevance to the short life span in the canola oil group. Enhanced Na(+), K(+)-ATPase activity by phytosterols in the oil ingested may play a role in these changes.
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Base de dados:
MEDLINE
Assunto principal:
Óleos de Plantas
/
Ácidos Graxos Monoinsaturados
/
Acidente Vascular Cerebral
/
Hipertensão
Tipo de estudo:
Incidence_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article