A neutropenia suggesting an interaction between valacyclovir and mycophenolate mofetil.
Clin Transplant
; 17(2): 158-61, 2003 Apr.
Article
em En
| MEDLINE
| ID: mdl-12709084
ABSTRACT
Mycophenolate mofetil (MMF) is a drug which decreases the frequency of renal transplantation rejection. However, cytomegalovirus infections are a common feature of this treatment leading the physicians to prescribe antiviral prophylactic drugs like valacyclovir. During this association, neutropenia occur and the cause of this adverse effect is difficult to define. This report presents a case of neutropenia in a woman treated with MMF and valacyclovir. As the duration of the valacyclovir treatment exactly corresponds to the neutropenia duration, and the mycophenolate trough levels increased with the neutrophil count, the responsibility of this neutropenia was ascribed to valacyclovir. However, an examination of the literature for cases of neutropenia led to the suspicion of an interaction between MMF and valacyclovir. Mycophenolate may increase intracellular concentrations of valacyclovir up to haematotoxic levels. This mechanism may explain the interaction and further research is needed to confirm this interaction.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Valina
/
Aciclovir
/
Imunossupressores
/
Ácido Micofenólico
/
Neutropenia
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article