New antimicrobial alkaloids from the roots of Polyalthia longifolia var. pendula.
Planta Med
; 69(4): 350-5, 2003 Apr.
Article
em En
| MEDLINE
| ID: mdl-12709903
ABSTRACT
Bioassay-guided isolation studies on the root extract of Polyalthia longifolia var. pendula possessing significant antibacterial activity led to the isolation of three new alkaloids pendulamine A (1), pendulamine B (2) and penduline (3) along with stigmasterol 3-O-beta-D-glucoside, allantoin, the known diterpenoid kolavenic acid, and the azafluorene alkaloid isoursuline. The structures of these compounds have been elucidated with the help of spectroscopic studies including 2D NMR experiments. Compounds 1 and 2, which are the only protoberberine alkaloids having a monosubstituted A ring with a hydroxy group at C-3, were found to be the active antibacterial principles of the roots. Their MIC values ranged between 0.02-20 microg against the tested bacteria.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Polyalthia
/
Bactérias Gram-Negativas
/
Bactérias Gram-Positivas
/
Fitoterapia
/
Antibacterianos
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article