Changes in blood viscosity with synthetic protease inhibitors.
J Pharmacol Sci
; 91(4): 334-6, 2003 Apr.
Article
em En
| MEDLINE
| ID: mdl-12719663
ABSTRACT
We examined the effects on whole blood viscosity and coagulation time of various dosages of the synthetic low-molecular protease inhibitors gabexate mesilate and nafamostat mesilate with an oscillation-type viscometer. When either agent was added, blood viscosity decreased dose-dependently along a sigmoid-like curve. Furthermore, coagulation time was shorter with gabexate mesilate than with nafamostat mesilate owing to the differences of half-life in human blood. Thrombin generation, which results from the activation of coagulation factors, is inhibited by synthetic protease inhibitors and subsequently decreases blood viscosity dose-dependently.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteases
/
Viscosidade Sanguínea
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article