Large volume donor plasmapheresis in inherited thrombophilia implicated in arterial thrombosis.
Transfus Apher Sci
; 28(3): 201-6, 2003 Jun.
Article
em En
| MEDLINE
| ID: mdl-12725943
ABSTRACT
BACKGROUND:
Life-threatening complications following apheresis are rare, and include venous thrombosis. Arterial thrombosis following apheresis has not been reported. CASE REPORT A 48 year old donor had cerebral infarction following large volume plasma donation. The outcome was fatal. He was found to be heterozygous for both methylene tetrahydrofolate reductase (MTHFR) 677C-T mutation and Prothrombin 20210G-A allele.CONCLUSION:
This case suggests that large volume plasma donation may trigger arterial thrombotic events in inherited thrombophilia. Therefore, the effects of plasmapheresis on coagulation system should be studied thoroughly.
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Base de dados:
MEDLINE
Assunto principal:
Trombose
/
Plasmaferese
/
Trombofilia
Tipo de estudo:
Etiology_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article