Long-lasting anticryptosporidial activity of nitazoxanide in an immunosuppressed rat model.
Folia Parasitol (Praha)
; 50(1): 19-22, 2003 Mar.
Article
em En
| MEDLINE
| ID: mdl-12735719
ABSTRACT
Cryptosporidium parvum, Tyzzer, 1912 is identified as a common cause of diarrhoea in immunocompetent individuals. In immunocompromised, especially HIV-infected subjects, cryptosporidiosis causes severe chronic diarrhoea. In this study, nitazoxanide (NTZ) was compared for curative activity with sinefungin (SNF) and paromomycin (PRM) in immunosuppressed rats, a screening model for anticryptosporidial agents. NTZ at either 50 mg/kg/day, 100 mg/kg/day or 200 mg/kg/day resulted in seven days in a dose-dependent inhibition of oocyst shedding similar to that obtained with SNF (10 mg/kg/day) and PRM (100 mg/kg/day). Further discontinuation of SNF or PRM 100 mg/kg/day therapy resulted in early relapse of oocyst shedding which reached the pre-treatment levels in 2-4 days. In contrast, seven days after discontinuation of therapy, shedding inhibition was unchanged in NTZ-treated rats. Data prompt further assessment of the activity of NTZ on sequestered C. parvum.
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Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Adenosina
/
Cryptosporidium parvum
/
Criptosporidiose
/
Antiprotozoários
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article