Amino acid-derived heterocycles as combinatorial library targets: bicyclic aminal lactones.
J Comb Chem
; 5(3): 278-84, 2003.
Article
em En
| MEDLINE
| ID: mdl-12739945
ABSTRACT
The incorporation of alpha-amino acids into heterocyclic structures is an effective strategy for generating peptidomimetics and combinatorial library scaffolds. This report describes the synthesis of novel bicyclic aminal lactones 3 by base-catalyzed cyclization of N-(2-oxoalkyl)-dipeptide esters 8. Assembly of the acyclic precursor 8 can be carried out on solid phase, with variation at four positions; cyclative release ensures high product purity in the final step. Cyclization affords the exo isomer stereospecifically when one chiral center is present in the precursor, or when both amino acids have the same configuration.
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Base de dados:
MEDLINE
Assunto principal:
Técnicas de Química Combinatória
/
Aminoácidos
/
Lactonas
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article