Renin-angiotensin system and atherothrombotic disease: from genes to treatment.
Arch Intern Med
; 163(10): 1155-64, 2003 May 26.
Article
em En
| MEDLINE
| ID: mdl-12767951
ABSTRACT
The renin-angiotensin system plays a central role in the pathogenesis of cardiovascular disease. At the molecular and cellular levels, angiotensin II, the main effector peptide of the system, stimulates key components of atherosclerosis. Trials in animals and humans indicate that blocking renin-angiotensin system pathways decreases atherosclerotic plaque progression and ischemic events. This review provides a broad overview of the entire role of the renin-angiotensin system in atherothrombotic disease, ranging from molecular pathways to human genetics to the latest clinical trials.
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Base de dados:
MEDLINE
Assunto principal:
Arteriosclerose
/
Sistema Renina-Angiotensina
/
Inibidores da Enzima Conversora de Angiotensina
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article