Plasma oxidative parameters and mortality in patients with severe burn injury.
Intensive Care Med
; 29(8): 1380-3, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-12774162
ABSTRACT
OBJECTIVE:
To determine xanthine oxidase and superoxide dismutase activities, lipid peroxidation, protein carbonylation, and total radical-trapping antioxidant parameter in survivors and nonsurvivors patients with severe burn injury. DESIGN ANDSETTING:
Prospective, comparative observational study in an intensive care unit, burn division, in a trauma hospital. PATIENTS Twenty-five consecutive patients who met the established criteria for severe burn injury (total burn surface area of more than 30%). MEASUREMENTS ANDRESULTS:
Plasma thiobarbituric acid reactive species and protein carbonyls levels were significantly higher in nonsurvivors than in survivors at 0 and 6 h. Elevated xanthine oxidase activity at 0 h was associated with adverse outcome after burn injury. In contrast, plasma superoxide dismutase activity and total radical-trapping antioxidant parameter did not differ significantly between nonsurvivors and survivors at any time point.CONCLUSIONS:
For the first time we demonstrate the value of oxidative parameters, namely thiobarbituric acid reactive species, protein carbonyls, and xanthine oxidase activity, in identifying burn patients with a poor prognosis. Whether these parameters are merely markers of clinical course, or whether they signal specific deleterious effects of oxidative stress during the burn injury remains to be elucidated.
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Base de dados:
MEDLINE
Assunto principal:
Superóxido Dismutase
/
Tiobarbitúricos
/
Xantina Oxidase
/
Queimaduras
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article