Microbial isoprenoid biosynthesis and human gammadelta T cell activation.
FEBS Lett
; 544(1-3): 4-10, 2003 Jun 05.
Article
em En
| MEDLINE
| ID: mdl-12782281
ABSTRACT
Human Vgamma9/Vdelta2 T cells play a crucial role in the immune response to microbial pathogens, yet their unconventional reactivity towards non-peptide antigens has been enigmatic until recently. The break-through in identification of the specific activator was only possible due to recent success in a seemingly remote field the elucidation of the reaction steps of the newly discovered 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway of isoprenoid biosynthesis that is utilised by many pathogenic bacteria. Unexpectedly, the intermediate of the MEP pathway, (E)-4-hydroxy-3-methyl-but-2-enyl-pyrophosphate) (HMB-PP), turned out to be by far the most potent Vgamma9/Vdelta2 T cell activator known, with an EC(50) of 0.1 nM.
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Base de dados:
MEDLINE
Assunto principal:
Açúcares de Poli-Isoprenil Fosfato
/
Bactérias
/
Linfócitos T
/
Receptores de Antígenos de Linfócitos T gama-delta
/
Difosfatos
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article