The effect of D-norgestrel, 30 micrograms, on the oral glucose tolerance test, including insulin levels, in Thai women.

ABSTRACT

PIP: Oral glucose tolerance tests were performed on 49 Thai women to inve stigate the effect of d-norgestrel (30 mcg) on carbohydrate metabolism. At 60 minutes, women who had taken d-norgestrel for 6 and 12 months showed a significant increase in blood glucose levels (p less than .05). There was a significant increase in blood insulin levels at 90, 120, 150, and 180 minutes in both groups (p less than .05). However, fa sting blood glucose or insulin levels were not markedly different. It is concluded that d-norgestrel, at the dose studied, affects carbohydrat e metabolism in Thai women, and it is suggested that this may be a characteristic effect of 19-nor steroids.