Propolis: lymphocyte proliferation and IFN-gamma production.
J Ethnopharmacol
; 87(1): 93-7, 2003 Jul.
Article
em En
| MEDLINE
| ID: mdl-12787960
ABSTRACT
We evaluated propolis influence on polyclonal activation of lymphocytes by concanavalin A (Con A). The in vitro experiments showed that propolis decreases splenocyte proliferation both in the absence or presence of Con A. The suppression in mitogen-induced splenocyte proliferation also occurred when mice were treated intraperitoneally with propolis for 3 days. An increased of IFN-gamma production in the culture supernatants of the same cells was observed. A dual action of propolis on lymphocyte activation was proposed it decreases splenocyte proliferation in the presence or absence of Con A and stimulates IFN-gamma production by spleen cells. These results are important to understand the immunomodulatory action of propolis on the host's specific and non-specific immunity.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Própole
/
Linfócitos
/
Interferon gama
/
Anti-Infecciosos
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article