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Simian immunodeficiency virus infection of CD4+CD8+ T cells in a macaque with an unusually high peripheral CD4+CD8+ T lymphocyte count.
Khatissian, Emmanuel; Monceaux, Valérie; Cumont, Marie-Christine; Ho Tsong Fang, Raphaël; Estaquier, Jérôme; Hurtrel, Bruno.
Afiliação
  • Khatissian E; Unité de Physiopathologie des Infections Lentivirales, Institut Pasteur, 75724 Paris Cedex 15, France. ekhatiss@pasteur.fr
AIDS Res Hum Retroviruses ; 19(4): 267-74, 2003 Apr.
Article em En | MEDLINE | ID: mdl-12804002
We assessed the possible role in vivo CD4(+) CD8(+) T cells as a viral reservoir for simian immunodeficiency virus (SIV), in a macaque with 50% CD4(+) CD8(+) T cells in peripheral blood. During primary infection (day 14) of this rhesus macaque with the pathogenic SIVmac251 strain, proviruses were detected at similar frequencies in CD4(+) CD8(+) T cells (1/10) and CD4(+) T cells (1/10) and at a lower frequency in CD8(+) T cells (1/800). On day 235, no viral DNA was detected in CD8(+) cells, despite the persistent high viral load, indicating that CD8(+) cells do not constitute a reservoir during the chronic phase of SIV infection. Infection induced early lymphopenia of CD4(+), CD4(+) CD8(+), and CD8(+) cells; only the CD8(+) cell population returned to initial levels and expanded further. We found that CD4(+) CD8(+) T cells expressed the costimulatory CD28 molecule less and were more prone to die in vitro after phytohemagglutinin/interleukin 2 stimulation than were CD4(+) T cells. Taken together, massive death of CD4(+) CD8(+) T cells during acute stages of SIV infection may explain why CD8(+) T cells did not represent a major reservoir for SIV at the onset of infection.
Assuntos
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Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Síndrome de Imunodeficiência Adquirida dos Símios / Vírus da Imunodeficiência Símia / Linfócitos T CD8-Positivos Limite: Animals Idioma: En Ano de publicação: 2003 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Síndrome de Imunodeficiência Adquirida dos Símios / Vírus da Imunodeficiência Símia / Linfócitos T CD8-Positivos Limite: Animals Idioma: En Ano de publicação: 2003 Tipo de documento: Article