Modulation of the induction of nitric oxide synthase by eicosanoids in the murine macrophage cell line J774.
Br J Pharmacol
; 107(3): 640-1, 1992 Nov.
Article
em En
| MEDLINE
| ID: mdl-1282071
ABSTRACT
The effect of eicosanoids on the induction of nitric oxide synthase in the murine macrophage cell line J774 has been studied. We found that prostaglandin E2 (PGE2) and iloprost (a stable analogue of prostacyclin) both at nanomolar concentrations inhibited the lipopolysaccharide stimulated induction of NO synthase. In contrast PGF2 alpha, U46619, a stable analogue of thromboxane A2, leukotrienes B4 and C4 had no effect. These data demonstrate that the L-arginine NO pathway in macrophages may be modulated by prostanoids.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Eicosanoides
/
Aminoácido Oxirredutases
/
Macrófagos
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article