Multiple copies of KIR 3DL/S1 and KIR 2DL4 genes identified in a number of individuals.
Hum Immunol
; 64(7): 729-32, 2003 Jul.
Article
em En
| MEDLINE
| ID: mdl-12826375
Multiple copies of the killer immunoglobulin-like receptor gene, 3DL/S1, have been identified in certain individuals. Additionally, allele determination of the killer immunoglobulin-like receptor gene (KIR), 2DL4, has identified three alleles of this gene present in these same individuals. This event has been confirmed by isolating three distinct KIR2DL4 allele clones in each individual, which sequenced as the alleles identified by the allele identification technique. It is our assumption that an unequal crossover event has occurred between differing KIR haplotypes resulting in the duplication of the 2DL4, 3DS1/3DL1 genes on the newly formed haplotype(s).
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Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Receptores Imunológicos
/
Dosagem de Genes
/
Duplicação Gênica
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article