cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles.
Biosci Biotechnol Biochem
; 67(5): 973-9, 2003 May.
Article
em En
| MEDLINE
| ID: mdl-12834273
ABSTRACT
Although expression of natriuretic peptides in cardiac tissues is up-regulated in response to pressure overload, no significant change in cGMP level in hypertrophied ventricles was observed. Activities of two cyclic nucleotide phosphodiesterase (PDE) isoforms, Ca2+/calmodulin-stimulated PDE (PDE1) and cGMP-stimulated PDE (PDE2), were significantly higher in rat left ventricles 14 days after aortic banding. The absence of significant changes in PDE1A and PDE2A mRNA levels indicated that the two PDE activities were post-transcriptionally up-regulated. These results suggested that the increased cGMP-PDE activity in response to pressure overload plays an important role in neutralizing cGMP action in cardiac tissue.
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Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Regulação para Cima
/
3',5'-GMP Cíclico Fosfodiesterases
/
Coração
/
Miocárdio
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article