[Methods of screening for adult celiac disease in patients attending ambulatory care service in immunology]. / A felnóttkori coeliakia felismerésének lehetósége szúróvizsgálatok alkalmazásával immunológiai szakambulancián jelentkezó betegekben.
Orv Hetil
; 144(22): 1069-76, 2003 Jun 01.
Article
em Hu
| MEDLINE
| ID: mdl-12847816
ABSTRACT
INTRODUCTION:
Coeliac disease (gluten sensitive enteropathy) is a very frequent disease appearing in variegated clinical form. In the last decade--concerning the immunogenetic and immunopathological aspects of the disease many of new recognition came to alight.AIM:
As the disease can lay hidden in its non classical manifesting form for a very long time, authors wished to study the efficacy of screening, which may be introduced for patients attending immunological outpatient care service. PATIENTS, METHODS ANDRESULTS:
In the frame of nation-wide patient care, out of the 200 potential patients sent for immunological check up, various form of coeliac disease was diagnosed in 20 cases. Among these cases there are two--presented for the first time--which are connected to bone marrow transplantation. Based on the immunogenetics and autoantibody serology as well as on small intestine biopsies the following conclusions were made.CONCLUSION:
1. Coeliac disease in Hungary is very frequent. Hidden disease should be considered first of all in cases of malabsorption symptoms. 2. Demonstration of autoantibodies on wide-scale palette helps to state the diagnosis based on the systematic auto-immune disease connection. 3. Study of Human Leukocyte Antigen allotype (HLA-DQA1*0501/DQBI*02) applied as marker can considerably support the suspicion of disease. 4. Histology test of the small intestine cannot be omitted.
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Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Doença Celíaca
/
Programas de Rastreamento
/
Assistência Ambulatorial
/
Intestino Delgado
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Hu
Ano de publicação:
2003
Tipo de documento:
Article