Cutting edge: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling.
J Immunol
; 171(3): 1128-32, 2003 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-12874197
ABSTRACT
The activation of biological T cell responses requires prolonged contact with APCs and sustained signaling. We investigated whether signaling must be uninterrupted to commit T cells to cytokine production or whether T cell activation may also result from summation of interrupted signals. Upon periodic addition and removal of a src kinase inhibitor, human CD4(+) T cells destroyed and re-formed immunological synapses while aborting and restarting signal transduction. Remarkably, under these conditions, T cells were eventually activated to IFN-gamma production and the amount of IFN-gamma produced was directly related to the total signaling time despite the repeated interruptions. Our results illustrate that T cell activation does not require a stable immunological synapse and can be achieved by interrupted signaling. It is implied that T cells can add activation signals, possibly collected on multiple APCs.
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Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
/
Linfócitos T
/
Transdução de Sinais
/
Comunicação Celular
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article