Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity.
Infect Immun
; 71(8): 4804-7, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-12874364
ABSTRACT
The roles of interleukin-4 (IL-4) and IL-13 in the regulation of immunity to Leishmania donovani infection are still poorly understood. Here we show that the increased parasite load observed in IL-4(-/-) and IL-4 receptor alpha(-/-) mice correlates with retarded granuloma maturation and antileishmanial activity and that the increased parasite load observed in IL-4 receptor alpha(-/-) mice correlates with increased NOS2 expression and decreased serum gamma interferon levels. IL-4 and IL-13 appear to play little role in regulating collagen deposition in L. donovani-induced granulomas.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interleucina-4
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Receptores de Interleucina-4
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Granuloma
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Leishmaniose Visceral
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Hepatopatias Parasitárias
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article