Effect of detergent on "promiscuous" inhibitors.
J Med Chem
; 46(16): 3448-51, 2003 Jul 31.
Article
em En
| MEDLINE
| ID: mdl-12877581
ABSTRACT
The term "promiscuous" inhibitors has been coined for compounds whose inhibition mechanism involves the interaction of aggregates of many compound molecules with the target protein, rather than the binding of individual molecules. This paper demonstrates that promiscuous inhibitors can be differentiated from classical 11 inhibitors by the judicious use of detergents, making it possible to configure assays that significantly reduce this undesirable mechanism of inhibition without compromising assay performance.
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Base de dados:
MEDLINE
Assunto principal:
Detergentes
/
Inibidores Enzimáticos
/
Inibidores de beta-Lactamases
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article