Virgin olive and fish oils enhance the hepatic antioxidant defence system in atherosclerotic rabbits.
Clin Nutr
; 22(4): 379-84, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-12880605
ABSTRACT
BACKGROUND & AIMS:
In this study we report the effects of sunflower, virgin olive and fish oils on the lipid profile and antioxidant defence system in liver mitochondria from rabbits with experimental atherosclerosis.METHOD:
An atherogenic control group were fed for 50 days on a diet containing 3% lard and 1.3% cholesterol. Four groups were fed for an additional period of 30 days with a diet enriched in different oils sunflower oil, virgin olive oil, refined olive oil and fish oil. A control group was fed with a standard chow.RESULTS:
The atherogenic diet caused important changes in the hepatic mitochondria lipid profile and in the enzymatic and non-enzymatic antioxidant defence system accompanied with an increase in the content of hydroperoxides in liver mitochondria. The administration of virgin olive and fish oils showed a better profile in the antioxidant system as well as decrease in the content of hydroperoxides.CONCLUSIONS:
The intake of cholesterol- and lard-enriched diet leads to a high impairment in the hepatic antioxidant defence system. However, the replacement of that diet by other unsaturated fat-enriched diets using virgin olive, sunflower and fish oil enhances hepatic antioxidant defence system, virgin olive and fish oil diet provide the best results.
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Base de dados:
MEDLINE
Assunto principal:
Arteriosclerose
/
Gorduras Insaturadas na Dieta
/
Mitocôndrias Hepáticas
/
Peróxidos Lipídicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article