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The emerging role of lysophosphatidic acid in cancer.
Mills, Gordon B; Moolenaar, Wouter H.
Afiliação
  • Mills GB; MD Anderson Cancer Center, Houston, Texas 77030, USA. gmills@mdanderson.org
Nat Rev Cancer ; 3(8): 582-91, 2003 Aug.
Article em En | MEDLINE | ID: mdl-12894246
The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.
Assuntos
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Base de dados: MEDLINE Assunto principal: Lisofosfolipídeos / Receptores Acoplados a Proteínas G / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2003 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Lisofosfolipídeos / Receptores Acoplados a Proteínas G / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2003 Tipo de documento: Article