The emerging role of lysophosphatidic acid in cancer.
Nat Rev Cancer
; 3(8): 582-91, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-12894246
The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.
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Base de dados:
MEDLINE
Assunto principal:
Lisofosfolipídeos
/
Receptores Acoplados a Proteínas G
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article