The relevance of alternative RNA splicing to pharmacogenomics.
Trends Biotechnol
; 21(8): 346-53, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-12902171
ABSTRACT
The importance of alternative RNA splicing in the generation of genetic diversity is now widely accepted. This article highlights how alternative RNA splicing can have an impact on drug efficacy and safety, and demonstrates its potential pharmacogenomic value. The analysis of the repertoire of alternative RNA splicing events could potentially identify markers of pharmacogenomic relevance with high sensitivity and specificity and also provides a route through which genes can be selected for single nucleotide polymorphism (SNP) genotyping. Recent methodological advances, including microarray and splice-dedicated expression profiling, have made it possible to perform high-throughput alternative splicing analyses.
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Base de dados:
MEDLINE
Assunto principal:
Farmacogenética
/
Processamento Alternativo
/
Predisposição Genética para Doença
/
Doenças Genéticas Inatas
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article