Concentration of caveolin-3 at the neuromuscular junction in young and old rat skeletal muscle fibers.
J Histochem Cytochem
; 51(9): 1113-8, 2003 Sep.
Article
em En
| MEDLINE
| ID: mdl-12923236
ABSTRACT
Caveolin-3, a muscle-specific member of the caveolin family, is strongly localized to the neuromuscular junction (NMJ) in adult rat muscle fibers, where it co-localizes with alpha-bungarotoxin staining. In 24-month-old rats, less distinct staining corresponds with the normal aging changes in the NMJ. After denervation, the pattern and intensity of staining begin to break up as early as 3 days, and by 10 days little staining remains. The functional implications of this concentration of caveolin-3 at the NMJ remain obscure, but it is possible that its absence could account for some of the phenotypic characteristics of individuals with caveolin-3 mutations.
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Base de dados:
MEDLINE
Assunto principal:
Músculo Esquelético
/
Fibras Musculares Esqueléticas
/
Caveolinas
/
Junção Neuromuscular
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article