Biologically active alkylated coumarins from Kayea assamica.
Phytochemistry
; 64(2): 535-41, 2003 Sep.
Article
em En
| MEDLINE
| ID: mdl-12943771
ABSTRACT
Four coumarin derivatives, theraphins A (1), B (2), C (3), and D (4), along with three known xanthones, 2-hydroxyxanthone, 1,7-dihydroxyxanthone, and 5-hydroxy-1-methoxyxanthone, were isolated from the bark of Kayea assamica (Clusiaceae) native to Myanmar. Their structures were determined using spectroscopic and chemical techniques. The absolute configuration of 1 was established by the modified Mosher ester method. Theraphins A (1), B (2), and C (3) exhibited good cytotoxicity against Col2, KB, and LNCaP human cancer cell lines. Theraphin D (4) showed mild activity only against the KB cell line. The coumarins also exhibited mild antimalarial activities.
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Base de dados:
MEDLINE
Assunto principal:
Cumarínicos
/
Clusiaceae
/
Antimaláricos
/
Antineoplásicos Fitogênicos
Limite:
Animals
/
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article