CD4+ T cell matters in tumor immunity.
Int Rev Immunol
; 22(2): 113-40, 2003.
Article
em En
| MEDLINE
| ID: mdl-12962272
ABSTRACT
CD4+ T cells have been shown to be able to affect tumor growth through both direct and indirect means. In addition, a requirement has been demonstrated for CD4+ T cells in the regulation and induction of T cell memory, and CD4+ suppressor T cells have been identified, stressing a role for CD4+ T cells in the induction and maintenance of antitumor immune responses. A review of the involvement of CD4+ T cells at different stages of tumor immunity is provided, and based on these data we discuss how CD4+ T cell response induction could be incorporated into tumor immunotherapy strategies.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article