[Effect of the number of CD34+CD38+ cells in cord blood on hematopoietic reconstitution in patients with acute leukemia after umbilical cord blood transplantation].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 11(4): 432-3, 2003 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-12962578
ABSTRACT
The objective of this research was to explore whether the number of CD34(+)CD38(+) cells infused affects hematopoietic reconstitution after cord blood transplantation. The number of CD34(+)CD38(+) cells in cord blood was analysed with flow cytometry after freezethawing. The body weight and time for neutrophil and platelet recovery were measured in 20 children with acute leukemia. The results showed that the median number of CD34(+)CD38(+) cells infused was 29.47 (9.85 - 325.71) x 10(4)/kg. A median time for neutrophil recovery (> 5 x 10(8)/L) in 20 patients was 18.5 (11 - 32) days, and time for platlet recovery (> 2 x 10(10)/L) in 19 of 20 patients was 45 (12 - 118) days. The number of CD34(+)CD38(+) cells infused correlated with time to neutrophil and platelet recovery (r = -0.577, P < 0.01 and r = 0.503, P < 0.05, respectively). In conclusion, the number of CD34(+)CD38(+) cells infused is correlated with the time for hematologic recovery.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
/
Antígenos CD
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Transplante de Células-Tronco Hematopoéticas
/
Antígenos CD34
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ADP-Ribosil Ciclase
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Sangue Fetal
/
Hematopoese
Limite:
Adolescent
/
Child
/
Child, preschool
/
Humans
Idioma:
Zh
Ano de publicação:
2003
Tipo de documento:
Article