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Myelin basic protein epitopes secreted by human T cells encounter natural autoantibodies in the serum.
Guerriero, Chiara; Zoccatelli, Gianni; Stefani, Elisabetta; Sartoris, Silvia; Cestari, Tiziana; Riviera, Anna Pia; Tridente, Giuseppe; Andrighetto, Giancarlo; Chignola, Roberto.
Afiliação
  • Guerriero C; Dipartimento di Patologia, Università di Verona, c/o Policlinico G.B. Rossi, I-37134 Verona, Italy.
J Neuroimmunol ; 141(1-2): 83-9, 2003 Aug.
Article em En | MEDLINE | ID: mdl-12965257
A previously isolated and characterized IgM monoclonal antibody (mAb 1H6.2) specific to myelin basic protein (MBP) and to MBP epitopes expressed by nonneural cells was used to immunoprecipitate and investigate the expression of MBP epitopes by human T cells. Peripheral T lymphocytes secreted MBP epitopes, and secretion increased in time after mitogen stimulation. Conversely, thymocytes secreted these proteins independently on mitogen stimulation. Specific antibody reactivity (primarily due to IgG3) towards immunoprecipitated MBP epitopes was found in all tested sera from healthy donors and from multiple sclerosis patients as well as in sera from normal human cord blood. Collectively, these data provide insights into the immunological mechanisms leading to central and peripheral tolerance to MBP products.
Assuntos
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Base de dados: MEDLINE Assunto principal: Autoanticorpos / Subpopulações de Linfócitos T / Epitopos de Linfócito T / Proteína Básica da Mielina Limite: Child, preschool / Humans Idioma: En Ano de publicação: 2003 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Autoanticorpos / Subpopulações de Linfócitos T / Epitopos de Linfócito T / Proteína Básica da Mielina Limite: Child, preschool / Humans Idioma: En Ano de publicação: 2003 Tipo de documento: Article