High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells.
Transpl Immunol
; 11(3-4): 245-58, 2003.
Article
em En
| MEDLINE
| ID: mdl-12967778
ABSTRACT
The direct interaction between antigen specific CD8(+) CD28(-) T suppressor cells (T(S)) with dendritic cells (DC) results in the tolerization of DC by inducing the upregulation of immunologlobulin like transcript 3 (ILT3) and ILT4. We show here that such tolerogenic DC anergize alloreactive CD4(+) CD45RO(+) CD25(+) T cells converting them into regulatory T cells (T(R)), which in turn, continue the cascade of suppression by tolerizing other DC. Interleukin 10 (IL-10) and interferon-alpha (IFN-alpha) also induce ILT3 and ILT4 upregulation in DC, rendering them tolerogenic. This implies a common mechanism of DC-mediated suppression. This finding and the observation that in organ allograft recipients quiescence is associated with the presence in the circulation of donor-specific T(S) and T(R) emphasize the importance of the cross talk between tolerogenic DC and T cells in suppression of the immune response.
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Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Receptores Imunológicos
/
Receptores de Superfície Celular
/
Tolerância ao Transplante
Limite:
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article