The Huntington's disease candidate region exhibits many different haplotypes.
Nat Genet
; 1(2): 99-103, 1992 May.
Article
em En
| MEDLINE
| ID: mdl-1302016
ABSTRACT
Analysis of 78 Huntington's disease (HD) chromosomes with multi-allele markers revealed 26 different haplotypes, suggesting a variety of independent HD mutations. The most frequent haplotype, accounting for about one third of disease chromosomes, suggests that the disease gene is between D4S182 and D4S180. However, the paucity of an expected class of chromosomes that can be related to this major haplotype by assuming single crossovers may reflect the operation of other mechanisms in creating haplotype diversity. Some of these mechanisms sustain alternative scenarios that do not require a multiple mutational origin for HD and/or its positioning between D4S182 and D4S180.
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Base de dados:
MEDLINE
Assunto principal:
Haplótipos
/
Doença de Huntington
Limite:
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article