Comparison of four computerized models to estimate 24-hour growth hormone secretion in girls with Turner's syndrome.
Horm Res
; 38(3-4): 125-33, 1992.
Article
em En
| MEDLINE
| ID: mdl-1306843
ABSTRACT
Daily pituitary growth hormone (GH) secretion can be estimated from a 24-hour GH profile by various methods. We have used four methods to assess GH secretion in 36 girls with Turner's syndrome the method described by Thompson et al., the Pulsar algorithm combined with the method of Hellman et al. and two deconvolution techniques. The number of detected peaks varied considerably among the methods. The mean (+/- SD) total daily secretion per square meter body surface was 0.53 (0.19) U/m2.day by deconvolution, in contrast to 0.31 (0.17) with the Hellman method and 1.06 (0.37) according to Thompson. The differences are explained by different assumptions about the metabolic clearance rate and various methodological aspects. Assuming a degradation rate of 50%, the growth hormone substitution dosage would be 1-2 IU/m2.day in GH-deficient children. The usual dosage in girls with Turner's syndrome is expected to lead to serum GH levels approximately 4 times higher than in the untreated state.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Turner
/
Simulação por Computador
/
Hormônio do Crescimento
Limite:
Adolescent
/
Child
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article