Genomic organization and analysis of the 5' end of the porcine ryanodine receptor gene (ryr1).
FEBS Lett
; 298(2-3): 277-9, 1992 Feb 24.
Article
em En
| MEDLINE
| ID: mdl-1312025
ABSTRACT
In this study we describe the isolation of genomic clones of the 5' region of the porcine ryanodine receptor gene, a candidate for malignant hyperthermia in pigs and humans. The recombinants were isolated from a porcine liver, genomic DNA library in phage EMBL3A after screening with PCR amplified DNA fragments. The exon/intron structure of the ryanodine receptor gene was determined by DNA sequencing. Based on the sequence data it was possible to develop a simple test for the detection of malignant hyperthermia susceptible and normal pigs.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Canais de Cálcio
/
Receptores Colinérgicos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article