EEG sleep in Cushing's disease and Cushing's syndrome: comparison with patients with major depressive disorder.
Biol Psychiatry
; 32(2): 146-55, 1992 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-1330006
ABSTRACT
Because patients with Cushing' syndrome (CS) and Major depressive disorder (MDD) share features of hypercortisolism and the depressive syndrome, we compared electro-encephalographic (EEG) sleep in patients with pituitary-ACTH-dependent Cushing's syndrome (Cushing's disease, CD), patients with ACTH-independent Cushing's syndrome (AICS), patients with major depressive disorder (MDD), and normal subjects. There were substantial similarities in the abnormal polysomnography profiles of patients with CD, AICS, and MDD. All three patient groups demonstrated poorer sleep continuity, shortened rapid eye movement (REM) latency, and increased first REM period density compared with normal subjects. In addition, AICS patients and MDD patients had elevated REM activity and density. These findings are discussed in terms of models of pathophysiology that relate abnormalities in sleep, mood, and hypothalamic-pituitary-adrenal function.
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Base de dados:
MEDLINE
Assunto principal:
Fases do Sono
/
Transtorno Bipolar
/
Processamento de Sinais Assistido por Computador
/
Hidrocortisona
/
Hormônio Adrenocorticotrópico
/
Transtornos Neurocognitivos
/
Síndrome de Cushing
/
Transtorno Depressivo
/
Eletroencefalografia
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article